Systematic reviews published recently also concluded that both PV and PK are safe and efficacious percutaneous interventions in treating VCFs [ , ]. The technique became popular among radiologists and patients for rapid pain relief and over time was modified in terms of materials and methods to minimize the risk of extravasation, thereby increasing safety. However, studies revealed that it would be inappropriate for use for vertebral augmentation procedures due to its inability to provide adequate spinal alignment [ 41 — 43 ]. Effect of strontium salt S on both tibial metaphysis and epiphysis in normal growing rats. Chubinskaya S, Kuettner KE.

The bonding of prostheses to bone by cement. Percutaneous vertebroplasty for malignant compression fractures with epidural involvement. Patients were randomly divided into 2 groups: They are sold under different brand names differing slightly in composition: Hulme et al reported the rates of neurological complications with PV and PK were 0. A small amount of inhibitor, typically hydroquinone, is also added to the liquid phase to avoid premature polymerization [ 19 ]. Among these 35, there was no study that qualified for Level I ranking, and a single Level II study was published in 2 separate manuscripts [ 89 , 90 ].

The biomechanical effects of kyphoplasty on treated and adjacent non treated vertebral bodies. This provided immediate pain relief after curing of bone cement, suggesting the restoration of mechanical stability in a clinical outcome study [ 72 thexis.

The first human in vivo study for measuring the polymerization temperature of different bone cements was performed by Anselmetti et al.

To initiate the polymerization at room temperature, N, N -dimethyltoluidine DMT is generally incorporated into the liquid phase as an activator. Therefore, VBS can be considered as a promising candidate for vertebral augmentation. Kyphoplasty also bnoe improved the quality of life, but here again, due to different outcome measurements for vertebroplasty, the data cannot be compared.


Seppalainen AM, Rajaniemi R.

In the first study, greater pain relief and faster return to daily activity was reported within 3—6 months of treatment in the KP cohort relative to OPM. Pulmonary embolism of polymethyl methacrylate during percutaneous vertebroplasty and kyphoplasty. Footnotes Source of support: Degenerative lumbar spinal stenosis: Other complications include epidural hematoma, partial motor loss [ ], and digestive tract bleeding [ ]. Efficacy and safety of balloon kyphoplasty in the treatment of vertebral compression fractures: Clin Biomech Bristol, Avon ; 20 1: A small amount of inhibitor, typically hydroquinone, is also added to the liquid phase to avoid premature polymerization [ 19 ].

Complications related to the use of bone bon and bone void fillers in treating compression fractures of the spine. Balloon kyphoplasty of vertebral compression fractures with a new calcium phosphate cement. Observations upon the interface between bone and polymethylmethacrylate cement. Percutaneous vertebroplasty in cemenf and malignant vertebrpolasty.

vertebroplasty bone cement thesis

Percutaneous vertebroplasty for pain relief and spinal stabilization. Vertebro;lasty, the Nitinol VerteLift implant can prevent the loss of vertebral height intra-operatively and postoperatively, as these implants are designed to flex around the end plates, thereby broadening the pressure distribution and preventing end plate damage.

Current status of percutaneous vertebroplasty and percutaneous kyphoplasty – a review

Most of the PK studies showed lower incidences of cement leakage compared to PV. The remaining 70 nonrandomized studies in the Vertebroplastu IV category showed substantial and rapid pain relief, although there was no control OPM group.

vertebroplasty bone cement thesis

According to the level of evidence rated by NASS, among 74 vretebroplasty articles on PV untilonly 1 article classifies as Level I randomized control trial [ 75 ], 3 articles qualify for Level II nonrandomized control trials [ 76 — 78 ], while the remaining 70 classify as Level IV [ bobe — 86 ] only a few representative references are cited here; for a comprehensive list please refer to the review by McGirt et al.


In percutaneous vertebroplasty, bone cement is injected through a minimal incision into the fractured site. The Kallem et al study included follow-up results from 1—3 months, whereas Buchbinder et al reported upto 6 months follow-up.

Antibiotic-impregnated acrylic bone cement.

vertebroplasty bone cement thesis

Thus the immediate pain relief after PV or PK can easily be related to the cessation of the cleft motion after curing of the bone cement. Vertebral cancellous bone can also be a source of pain.

Improved vertebral height restoration with PK is also controversial, because initial height gain is higher in kyphoplasty but this effect is lost subsequently during balloon deflation and repetitive loading.

Current status of percutaneous vertebroplasty and percutaneous kyphoplasty – a review

However, the selection of application of procedures was notably biased, with more none VCFs receiving kyphoplasty. Both PV and KP can provide pain relief and vertebroplatsy benefits to patients, with acceptable safety when used by skilled physicians. J Bone Miner Res. PV and KP are the most routinely used minimally invasive procedures to treat osteoporotic or tumor-associated VCFs with the primary aim of relieving pain. Comparative study of biphasic calcium phosphate ceramics impregnated with rh-BMP-2 as bone substitutes.

As mentioned above, the bone cement consists of 2 parts: In vitro evaluation of orthopedic composite cytotoxicity: